Question

Infection with Clonorchis sinensis is associated with an increased risk of__?

• A. Cervical cancer
• B. Cholangiocarcinoma
• C. Gastric carcinoma
• D. Bladder carcinoma

Answer 1

The Correct Option is B

Infection with Clonorchis sinensis, also known as the Chinese liver fluke, is primarily linked to an increased risk of cholangiocarcinoma. This association is due to the parasite's lifecycle and its effects on the liver and bile ducts. Here’s how the infection contributes to the risk:

• Life Cycle Involvement: Clonorchis sinensis infects the bile ducts of the human liver. During their lifecycle, these worms cause continuous irritation and inflammation within the bile ducts.
• Chronic Inflammation: The presence of the parasite leads to chronic inflammation, a key factor in cellular mutations and damage.
• Biliary Obstruction: Persistent infection can cause biliary obstruction and cholangitis, further increasing the risk of malignant transformation.
• Cellular Changes: Chronic infection is associated with increased cellular proliferation and genetic mutations, creating a conducive environment for the development of cholangiocarcinoma, which is a type of cancer originating from the biliary epithelium.

Among the options provided, cholangiocarcinoma is the correct answer, as it most directly correlates with the biological and pathological impact of a Clonorchis sinensis infection.