In humans, the sex chromosomes (X and Y) are responsible for sex determination.
- Females have two X chromosomes $(XX)$.
- Males have one X and one Y chromosome $(XY)$.
The sperm determines the sex of the offspring:
- If the sperm carries an $X$ chromosome $\Rightarrow$ the child will be female $(XX)$.
- If the sperm carries a $Y$ chromosome $\Rightarrow$ the child will be male $(XY)$.
Final Answer:
\[
\boxed{\text{Sex chromosomes (X and Y) determine sex in humans.}}
\]