Question

In HPLC analysis, what type of column is preferred?

• A. A column with high HETP and high number of plates
• B. A column with low HETP and low number of plates
• C. A column with high HETP and low number of plates
• D. A column with low HETP and high number of plates

Hint:

Low HETP + High number of plates = High resolution in HPLC.

Answer 1

The Correct Option is D

In HPLC, the efficiency of a column is determined by the height equivalent to a theoretical plate (HETP) and the number of theoretical plates. A low HETP and high number of plates indicate high column efficiency and better separation capability.