Question:

In HPLC analysis, what type of column is preferred?

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Low HETP + High number of plates = High resolution in HPLC.
Updated On: Jun 16, 2025
  • A column with high HETP and high number of plates
  • A column with low HETP and low number of plates
  • A column with high HETP and low number of plates
  • A column with low HETP and high number of plates
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The Correct Option is D

Solution and Explanation

In HPLC, the efficiency of a column is determined by the height equivalent to a theoretical plate (HETP) and the number of theoretical plates. A low HETP and high number of plates indicate high column efficiency and better separation capability.
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