Question:
In cytotoxic induced drug vomiting, which of the following receptor is most involved?
In cytotoxic induced drug vomiting, which of the following receptor is most involved?
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Remember the link between chemotherapy, gut damage, serotonin release, and the 5-HT$_3$ receptor's role in triggering vomiting.
Updated On: May 6, 2025
- \( \text{Histamine H}_1 \text{ receptor} \)
- \( \text{Serotonin 5-HT}_3 \text{ receptor} \)
- \( \text{Dopamine D}_2 \text{ receptor} \)
- \( \text{Opioid } \mu \text{ receptor} \)
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The Correct Option is B
Solution and Explanation
Cytotoxic drugs used in chemotherapy can induce vomiting by damaging enterochromaffin (EC) cells in the gastrointestinal tract. These damaged EC cells release serotonin (5-hydroxytryptamine, 5-HT), which then activates 5-HT$_3$ receptors located on vagal afferent nerve terminals in the gut. These signals are transmitted to the vomiting center in the brainstem, triggering emesis. Therefore, the serotonin 5-HT$_3$ receptor plays a crucial role in cytotoxic drug-induced vomiting, and 5-HT$_3$ receptor antagonists are effective antiemetics in this context.
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