Question

In Bartter syndrome defect is seen in:

• A. Defect in PCT
• B. Defect in DCT
• C. Defect in thick ascending limb of loop of henle
• D. None

Answer 1

The Correct Option is C

Bartter syndrome is a group of disorders characterized by defective transport mechanisms in the nephron, specifically affecting the thick ascending limb of the loop of Henle. This condition leads to imbalances such as hypokalemia, metabolic alkalosis, and hypercalciuria due to impaired sodium chloride reabsorption.

In the context of the options provided:

• Defect in PCT (Proximal Convoluted Tubule) - Incorrect. Bartter syndrome does not involve defects in this area; instead, it affects the loop of Henle.
• Defect in DCT (Distal Convoluted Tubule) - Incorrect. While certain renal disorders involve the DCT, Bartter syndrome primarily impacts the loop of Henle.
• Defect in thick ascending limb of loop of Henle - Correct. This is the characteristic defect in Bartter syndrome, resulting in impaired reabsorption of electrolytes.
• None - Incorrect. There is a specific defect in Bartter syndrome.

Based on the above understanding, the correct choice is the defect in the thick ascending limb of the loop of Henle, as this is where Bartter syndrome manifests its primary transport dysfunctions.