Idea. Two lines are perpendicular in 3-D exactly when the dot product of any direction-ratio triples is \(0\). Dot product adds the products of the matching components. Step 1. Compute the dot product and set it to zero.
\[
(2,3,5)\cdot(x,y,4)=2x+3y+5\cdot 4=0.
\]
Step 2. Simplify.
\[
2x+3y+20=0\Rightarrow 2x+3y=-20.
\]
That is the required value.