Step 1: Use the properties of hyperbolas.
The length of the latus rectum of a hyperbola is given by:
\[
\text{Length of latus rectum} = \frac{2b^2}{a}.
\]
We are given that the length of the latus rectum is 8, so:
\[
\frac{2b^2}{a} = 8.
\]
This gives the relation between \( a \) and \( b \).
Step 2: Use the coordinates of point \( P(10, 2\sqrt{15}) \).
Since the point lies on the hyperbola, substitute \( x = 10 \) and \( y = 2\sqrt{15} \) into the equation of the hyperbola:
\[
\frac{10^2}{a^2} - \frac{(2\sqrt{15})^2}{b^2} = 1.
\]
This gives another equation involving \( a \) and \( b \).
Step 3: Solve the system of equations.
By solving these equations, we find the values for \( a \) and \( b \), and then calculate the square of the area of \( \Delta PS_1S_2 \).
Final Answer:
\[
\boxed{2700}.
\]