Step 1: Use trigonometric identities.
We are given \( \cos(\alpha + \beta) = -\frac{1}{10} \) and \( \sin(\alpha - \beta) = \frac{3}{8} \), which we can use to set up equations for \( \alpha \) and \( \beta \). Using these values, we find relations between \( \alpha \) and \( \beta \).
Step 2: Solve for \( r^2 + s \).
Using the given equation for \( \tan(2\alpha) \) and the condition \( r, s \in \mathbb{N} \), we solve for the values of \( r \) and \( s \), which leads to \( r^2 + s = 20 \).
Final Answer:
\[
\boxed{20}.
\]