Question

Glucose does not react with:

• A. Conc. HNO₃
• B. Acetic Anhydride
• C. Hydroxylamine
• D. Sodium bisulphite

Hint:

Glucose reacts with concentrated nitric acid, acetic anhydride, and hydroxylamine due to the presence of its aldehyde group and hydroxyl groups, but it does not react significantly with sodium bisulphite under normal conditions.

Answer 1

The Correct Option is D

Glucose, a reducing sugar, can undergo various reactions due to its aldehyde group (in the open-chain form) and hydroxyl groups. Let’s analyze the options:
1. Conc. HNO₃ (Concentrated Nitric Acid): Glucose reacts with concentrated nitric acid to give glucaric acid (a sugar acid) through oxidation. Hence, glucose reacts with concentrated HNO₃.
2. Acetic Anhydride: Glucose reacts with acetic anhydride to form acetates (esters) by esterification of the hydroxyl groups.
Therefore, glucose reacts with acetic anhydride.
3. Hydroxylamine: Hydroxylamine reacts with aldehydes, such as the aldehyde group in glucose, to form oximes.
Therefore, glucose reacts with hydroxylamine.
4. Sodium bisulphite: Sodium bisulphite reacts with aldehydes to form adducts, but glucose does not react with sodium bisulphite in the same manner as aldehydes or ketones. Glucose’s aldehyde group in the open-chain form is not easily reactive with sodium bisulphite compared to other aldehydes.
Thus, the correct answer is Sodium bisulphite.