Question

Given below are two statement - one is labelled as Assertion A and the other is labelled as Reason R: 
Assertion A: Bacterial lipopolysaccharide (LPS) on its own does not induce memory B-cell in humans.
Reason R: LPS does not activate T-cell.
In light of the above statements, choose the most appropriate answer from the options given below:

• A. Both A and R are correct and R is the correct explanation of A
• B. Both A and R are correct, but R is NOT the correct explanation of A
• C. A is correct but R is not correct
• D. A is not correct but R is correct

Hint:

T-independent antigens like LPS stimulate antibody production without T-cell help, but do not induce memory B-cells due to lack of T-cell activation.

Answer 1

The Correct Option is A

Step 1: Understand LPS and immune cell activation.
LPS (lipopolysaccharide) is a T-independent antigen, which can stimulate B-cells to produce antibodies, but does not lead to memory B-cell formation because this process requires T-cell help. 
Step 2: Examine the reason. 
LPS directly activates B-cells, but not T-cells, which are crucial for the development of memory responses. Therefore, the lack of T-cell activation explains the absence of memory B-cell formation. 
Step 3: Conclusion. 
Both Assertion (A) and Reason (R) are true, and R correctly explains A.