We are asked to differentiate:
\[
\frac{d}{dx} \left( \cos(\pi x + \sin \pi x) \right)
\]
Use the chain rule for differentiation. First, differentiate the outer function:
\[
\frac{d}{dx} \cos(u) = -\sin(u)
\]
where \( u = \pi x + \sin \pi x \).
Next, differentiate the inner function \( u \):
\[
\frac{d}{dx} (\pi x + \sin \pi x) = \pi + \cos(\pi x) \cdot \pi
\]
Thus, the final derivative is:
\[
\frac{d}{dx} \left( \cos(\pi x + \sin \pi x) \right) = -\sin(\pi x + \sin \pi x) \cdot \pi
\]
Thus, the correct answer is \( - \pi \sin(\pi x) \).