Question

Formation of white powdery deposit on the surface of suppository on storage is called _______

• A. \( \text{Orange peel} \)
• B. \( \text{Fragility} \)
• C. \( \text{Bloom} \)
• D. \( \text{Syneresis} \)

Hint:

Associate the term "bloom" with the white powdery appearance on the surface of chocolate or fat-based pharmaceutical products like suppositories.

Answer 1

The Correct Option is C

The formation of a white powdery deposit on the surface of suppositories, particularly those with a fatty base (like cocoa butter), during storage is known as "bloom." This phenomenon is usually due to the recrystallization of some of the fat components, especially lower melting point triglycerides, on the surface. It can alter the appearance and potentially the drug release profile of the suppository. Orange peel refers to a mottling or uneven surface appearance. Fragility is the tendency of the suppository to break or crumble. Syneresis is the expulsion of liquid from a gel.