Question

For the work on split genes, who won Nobel Prize of Medicine in 1993?

• A. Gilbert and co-workers
• B. Sharp and Roberts
• C. Chambon and co-workers
• D. Hogness and co-workers

Hint:

Split genes = Exons + Introns. Discovery explained RNA splicing mechanism.

Answer 1

The Correct Option is B

Step 1: Define split genes.
Split genes are genes in which coding sequences (exons) are interrupted by non-coding sequences (introns). This discovery revolutionized molecular biology and explained RNA splicing.
Step 2: Nobel Prize 1993.
In 1993, the Nobel Prize in Medicine was awarded jointly to Richard J. Roberts and Phillip A. Sharp for their discovery of split genes in adenovirus, which demonstrated the presence of introns and exons.
Step 3: Checking options.
- Gilbert → Known for DNA sequencing methods, not split genes.
- Sharp and Roberts → Correct, Nobel Prize 1993 winners.
- Chambon → Contributed to molecular biology, but not the Nobel Prize 1993 for split genes.
- Hogness → Known for Drosophila genetics, not split genes.
Step 4: Conclusion.
Hence, Sharp and Roberts won the Nobel Prize in 1993 for their discovery of split genes.