Question

Follicular lymphoma positivity?

• A. Bcl-1
• B. Bcl-6
• C. Bcl- 2
• D. None of the above

Answer 1

The Correct Option is C

Follicular lymphoma is a type of non-Hodgkin lymphoma, characterized by the proliferation of neoplastic follicular center B-cells (centerocytes and centeroblasts). A hallmark of follicular lymphoma is the chromosomal translocation t(14;18)(q32;q21), which results in the overexpression of the Bcl-2 gene. Bcl-2 is an anti-apoptotic protein that helps the lymphoma cells evade programmed cell death, contributing to the longevity and accumulation of these malignant cells. Therefore, Bcl-2 positivity is a common feature used in the diagnosis of follicular lymphoma.

Option	Explanation
Bcl-1	Not typically associated with follicular lymphoma; related to mantle cell lymphoma.
Bcl-6	Although Bcl-6 is expressed in some B-cell lymphomas and plays a role in lymphomagenesis, it is not the primary marker for follicular lymphoma identification.
Bcl-2	This is the correct answer, as Bcl-2 overexpression is directly linked to follicular lymphoma due to the characteristic chromosomal translocation.
None of the above	Incorrect, as Bcl-2 is indeed linked to follicular lymphoma.