Question

Fluoroquinolone contraindicated in liver disease is

• A. Levofloxacin
• B. Pefloxacin
• C. Ofloxacin
• D. Lomefloxacin

Answer 1

The Correct Option is B

To determine which fluoroquinolone is contraindicated in liver disease, it's essential to understand the metabolism of each drug. Fluoroquinolones are a class of antibiotics that are commonly used to treat various infections.

The focus is on how these drugs are processed in the body and which ones rely on hepatic (liver) metabolism and excretion. If a drug is heavily metabolized by the liver, it could be harmful or require dosage adjustments in patients with liver disease.

• Levofloxacin: Primarily excreted unchanged in the urine, indicating renal over hepatic metabolism.
• Pefloxacin: Extensively metabolized by the liver, making it problematic for patients with hepatic impairment.
• Ofloxacin: Similar to Levofloxacin, it is mainly eliminated by the kidneys.
• Lomefloxacin: Also predominantly cleared via renal pathways.

Considering these metabolic pathways, Pefloxacin is contraindicated in liver disease because it depends on the liver for metabolism, which could lead to accumulation and toxicity in patients with compromised liver function.