This question presents a higher level of difficulty. Initially, all the statements may seem interconnected. Option 2 emphasizes the creator's participation and imagination in making single-panel comics engaging and rewarding. The opening sentence can have two potential candidates, 1 or 2.
Sentence 1 aims to provide an intriguing example of inference found in single-panel comics. Inference involves arriving at conclusions based on evidence, a skill precisely exercised in single-panel comics. The viewer is presented with a panel and must imagine, through humor, what might have occurred just before or after, requiring inference to understand the joke. Therefore, 1 stands out as a better opening sentence. The sequence 1345 forms a coherent paragraph.
The reason why 2 cannot be the opening sentence is clarified by the fact that it mentions the creator's participation, while in this context, the creator is not actively participating but rather concealing something, prompting the viewer to use their imagination and make inferences.