Question:

Example of Non-Mendelian disorder:

Updated On: Apr 19, 2024
  • Cystic fibrosis
  • Haemophilia
  • Down’s syndrome
  • Thalassemia
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The Correct Option is C

Solution and Explanation

Down's syndrome is caused by the presence of an extra copy of chromosome 21, known as trisomy 21. It is not inherited in a Mendelian pattern, which typically involves the transmission of a single gene from parents to offspring. Instead, Down's syndrome occurs due to a random error during the formation of reproductive cells or early embryonic development.

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Concepts Used:

Non-Mendelian Genetics

The term - non-mendelian inheritance refers to any pattern of heredity in which features do not separate according to Mendel's laws. These principles describe how features linked with single genes on chromosomes in the nucleus are passed down through generations.

Types of Non-Mendelian Inheritance

Codominance Inheritance

It is a form of incomplete dominance in which both alleles for the same feature are expressed in the heterozygote at the same time. For example, the MN blood types of humans.

Incomplete Dominance

In a heterozygote, the dominant allele does not always completely cover the phenotypic expression of the recessive gene, resulting in an intermediate phenotype which is referred to as "incomplete dominance”.