Question

Disorder caused due to accumulation of amyloid proteins in CNS.

Hint:

When considering diseases linked to amyloid protein accumulation, Alzheimer's disease (AD) is the most well-known, but cerebral amyloid angiopathy (CAA) is another important condition to consider. Both involve amyloid buildup but affect different parts of the CNS.

Answer 1

Amyloid proteins accumulate abnormally in the central nervous system (CNS), leading to various neurological disorders. Alzheimer's disease (AD) is one of the most common disorders associated with the accumulation of amyloid plaques in the brain, which are composed of beta-amyloid proteins. These plaques disrupt communication between neurons and lead to neurodegeneration, which is characteristic of AD. However, another condition called cerebral amyloid angiopathy (CAA) is also related to amyloid accumulation, where amyloid deposits affect the blood vessels in the brain, increasing the risk of stroke and bleeding. Thus, both Alzheimer's disease and cerebral amyloid angiopathy are disorders caused by the accumulation of amyloid proteins in the CNS.