Step 1: Pulmonary Valve Dysfunction in TOF:
1. Pulmonary Valve Regurgitation (PVR): The most common indication for pulmonary valve replacement (PVR) in TOF patients is significant pulmonary valve regurgitation, which can lead to right ventricular dilation and failure.
2. Right Ventricular Dysfunction: If the right ventricle becomes significantly enlarged or shows signs of failure due to prolonged pressure overload, pulmonary valve replacement is recommended to relieve stress on the right ventricle.
3. Exercise Intolerance: Severe exercise intolerance caused by pulmonary valve insufficiency or right heart failure may indicate the need for valve replacement.