Question

Describe histopathologics Findings of :
Common variable immuno-deficiency (CVI.

Hint:

Histopathology in CVID shows lymphoid tissue hyperplasia, germinal center deficiency, and intestinal lymphocytic infiltration, highlighting immune dysregulation.

Answer 1

Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by low levels of immunoglobulins and an increased susceptibility to infections. Histopathologic findings in CVID include:
Step 1: Lymphoid Tissue Hyperplasia:
1. There is hyperplasia of lymphoid tissues, particularly in the lymph nodes and spleen, due to compensatory efforts in immune cell production.
Step 2: Germinal Center Deficiency:
1. Germinal centers in lymphoid tissues may be absent or poorly formed, reflecting impaired B-cell maturation.
Step 3: Intestinal Lymphocytic Infiltration:
1. There may be an increase in intraepithelial lymphocytes, similar to autoimmune enteropathy, and lymphocytic infiltration in the intestines.