Question

Describe histopathologics Findings of :
Celiac disease.

Hint:

Histopathologic examination showing villous atrophy, increased intraepithelial lymphocytes, and crypt hyperplasia is key to diagnosing celiac disease.

Answer 1

Histopathologic findings in celiac disease typically involve changes in the small intestine. The characteristic findings are as follows:
Step 1: Villous Atrophy:
1. There is partial or complete villous atrophy in the small intestine. The villi become shortened, resulting in a reduced absorptive surface area.
2. The degree of atrophy may vary from mild to severe, with complete loss of villi in severe cases.
Step 2: Increased Intraepithelial Lymphocytes:
1. There is an increased number of intraepithelial lymphocytes (IELs) in the epithelial lining of the intestine. This is a key diagnostic feature.
2. The number of IELs can be quantified and is typically higher than normal in celiac disease.
Step 3: Crypt Hyperplasia:
1. Crypts are elongated and hypertrophic. This is often seen as a response to villous atrophy.