Mass defect: The difference between the sum of the masses of individual nucleons and the actual mass of the nucleus.
\[
\Delta m = (Z m_p + N m_n) - M_{\text{nucleus}}
\]
Binding energy: The energy required to separate the nucleus into its individual nucleons.
\[
E_b = \Delta m \cdot c^2
\]
\[
\boxed{E_b = \Delta m \cdot c^2}
\]