Question

Considering the unique properties of nano materials, evaluate their use in targeted drug delivery systems.

• A. Highly effective due to their small size and surface area, allowing for precise targeting.
• B. Generally ineffective due to rapid clearance from the body.
• C. Effective but often lead to high toxicity and side effects.
• D. Ineffective due to instability in biological environments.

Hint:

Nanomaterials in Drug Delivery. Advantages stem from small size (penetration, accumulation) and large surface area (drug loading, surface functionalization for targeting). Allows for potentially precise delivery. Challenges include biodistribution, toxicity, stability.

Answer 1

The Correct Option is A

Nanomaterials (like nanoparticles, nanocapsules, dendrimers) offer unique advantages for targeted drug delivery: - Small Size: Allows them to potentially pass through biological barriers, circulate longer, and accumulate preferentially in certain tissues (e.
g.
, tumors via the Enhanced Permeability and Retention - EPR effect).
- Large Surface Area to Volume Ratio: Enables high drug loading capacity and provides ample surface area for modification with targeting ligands (antibodies, peptides) that can direct the nanoparticles specifically to diseased cells or tissues.
These properties contribute to the potential effectiveness of nanomaterials in achieving precise, targeted drug delivery, which can enhance therapeutic efficacy while reducing systemic side effects.
While challenges like clearance (Option 2), toxicity (Option 3), and stability (Option 4) exist and must be addressed in nanomaterial design, the fundamental reasons for their *potential effectiveness* lie in their size and surface properties allowing for targeting (Option 1).