Question

Choose the incorrect statements regarding Haemophilia
A. Haemophilia B is X-linked recessive disorder
B. Haemophilia C is autosomal dominant disorder
C. Haemophilia B is caused by deficiency of clotting factor IX
D. Haemophilia A is caused by deficiency of clotting factor XII

• A. A, C
• B. B, D
• C. B, C
• D. C, D

Hint:

Haemophilia A → Factor VIII deficiency
Haemophilia B → Factor IX deficiency
Haemophilia C → Rare, usually autosomal recessive

Answer 1

The Correct Option is B

Let’s analyze each statement: - A. Correct. Haemophilia B is indeed an X-linked recessive disorder.
- B. Incorrect. Haemophilia C is usually inherited in an autosomal recessive manner, not dominant.
- C. Correct. Haemophilia B is caused by a deficiency of clotting factor IX.
- D. Incorrect. Haemophilia A is caused by a deficiency of clotting factor VIII, not factor XII.
Hence, the incorrect statements are B and D.

Answer 2

The incorrect statements regarding Haemophilia are:

B. Haemophilia C is autosomal dominant disorder — This is incorrect because Haemophilia C is actually an autosomal recessive disorder caused by deficiency of clotting factor XI, not autosomal dominant.

D. Haemophilia A is caused by deficiency of clotting factor XII — This is incorrect because Haemophilia A is caused by deficiency of clotting factor VIII, not factor XII. Factor XII deficiency does not cause Haemophilia but may cause other coagulation abnormalities.

Statements A and C are correct:
- Haemophilia B is indeed an X-linked recessive disorder.
- Haemophilia B is caused by deficiency of clotting factor IX.

Hence, the incorrect statements are B and D.