In the context of biological and genetic conditions, certain physical features are associated with specific syndromes. For instance, one particular feature is the presence of a broad palm with a single transverse palmar crease, also known as a "simian line."
This specific feature is commonly associated with Down's syndrome, a genetic disorder caused by the presence of an extra chromosome 21. Down's syndrome often presents with various characteristic features, one of which includes the simian line in the palm.
Thus, when observing a person with a broad palm and a single palm crease, it is indicative of Down’s syndrome.