Question

Bernard–Soulier syndrome due to deficiency of

• A. Gp 2b/3a
• B. Gp 1b
• C. vWf
• D. TNF

Answer 1

The Correct Option is B

Bernard-Soulier Syndrome is a rare inherited bleeding disorder caused by a deficiency or dysfunction of a platelet membrane glycoprotein known as Gp 1b. This glycoprotein is a crucial part of the Gp Ib-IX-V complex that functions as a receptor for von Willebrand factor (vWF) on the platelet surface. The deficiency of Gp 1b impairs the platelets' ability to adhere to the subendothelial matrix at sites of vascular injury, leading to impaired hemostasis. This condition manifests with symptoms such as easy bruising, epistaxis, and prolonged bleeding from minor cuts. The correct answer to the question is option: Gp 1b.