Question

Assertion (A): Amides are formed due to the replacement of hydroxyl part in aminoacid by another NH$_2$ radicle.
Reason (R): Amides are formed by transamination reaction.
Identify the correct option from the following

• (A) and (R) are true. (R) is correct explanation for (A)
• (A) and (R) are true. But (R) is not correct explanation for (A)
• (A) is true, but (R) is false
• (A) is false, but (R) is true.

Hint:

Amide formation involves a condensation reaction (loss of water) between a carboxylic acid derivative and an amine. Transamination is an amino group transfer reaction, distinct from amide synthesis.

Answer 1

The Correct Option is A

Step 1: Understanding the assertion.
Amides are compounds where a hydroxyl group (–OH) of a carboxylic acid is replaced by an amino group (–NH\textsubscript{2}).
This process happens during peptide bond formation between amino acids, hence the assertion is correct. Step 2: Understanding the reason.
Transamination is a key biochemical reaction where an amino group is transferred, often initiating processes that can eventually form amide linkages (especially in biosynthesis).
So in a broader biochemical context, transamination contributes to the formation of amides, making the reason valid. Step 3: Conclusion.
Both Assertion and Reason are true, and Reason correctly explains the Assertion.