Although the hormone adrenaline is known to regulate memory storage, its effects on retrieval
are debated. Adrenaline’s modulation of retrieval is difficult to interpret because retrieval pro-
tocols usually involve new learning, which is known to be affected by adrenaline. Say, for
example, that researchers test the effect of adrenaline on participants’ ability to remember a
story. If participants are injected with adrenaline before being asked to recall the story, the
adrenaline might enhance or impair their recall performance not by affecting retrieval directly,
but rather by affecting their ability to learn the information presented in the retrieval protocol
(i.e., the researcher’s questions). To evaluate the hormone’s effect on retrieval without the
confounding effects of new learning, McGaugh and colleagues tested the effects of adrenaline on memory for intentionally forgotten information. Research has shown that when participants
are asked to memorize two lists (list 1 and list 2) and are then instructed to forget list 1,
they exhibit poorer recall of list 1 than do participants who are not instructed to forget it-a
phenomenon known as intentional forgetting. This phenomenon is attributed to retrieval inhi-
bition, a mechanism that makes the unwanted information less likely to be retrieved, whether
intentionally or unintentionally. McGaugh and colleagues reasoned that if adrenaline enhances
retrieval, it should reduce intentional forgetting. They hypothesized that participants given
adrenaline after being instructed to forget list 1 would recall more words from that list than
participants given a placebo. After participants memorized list 1, they were told to forget it
and memorize list 2. Immediately afterwards, they received an injection of either adrenaline
or a placebo and then completed a distractor task. Finally, they were asked to recall as many
words as possible from list 1. Adrenaline-treated participants did indeed recall significantly
more words from list 1 than placebo-treated participants, suggesting that adrenaline enhances
the retrieval of intentionally forgotten memories.