Question

Alpha one anti trypsin works by:

• A. inhibition of trypsin
• B. inhibition of trypsinogen
• C. inhibition of elastase
• D. inhibition of chymotrypsin

Answer 1

The Correct Option is C

Alpha-1 antitrypsin is a protein that primarily functions to protect tissues in the body from the enzyme neutrophil elastase. Neutrophil elastase is produced by white blood cells to break down harmful bacteria and engulf pathogens, but it can also damage body tissues if not properly regulated.

The options provided explore various enzymes that alpha-1 antitrypsin might inhibit. To determine the correct function, we clarify each potential interaction:

• Inhibition of trypsin: Trypsin is a serine protease involved in digestion, specifically in the breakdown of proteins in the small intestine. Alpha-1 antitrypsin does not target or inhibit trypsin.
• Inhibition of trypsinogen: Trypsinogen is the inactive form of trypsin. Alpha-1 antitrypsin does not function to inhibit this enzyme.
• Inhibition of elastase: Elastase is the enzyme that alpha-1 antitrypsin specifically inhibits. This function protects elastic tissues in the lungs and other organs from degradation.
• Inhibition of chymotrypsin: Chymotrypsin, like trypsin, is a digestive enzyme, and alpha-1 antitrypsin does not affect its activity.

Conclusively, the correct answer is inhibition of elastase. Alpha-1 antitrypsin counteracts elastase to prevent tissue damage, a crucial step in maintaining healthy lungs and preventing conditions such as emphysema.