Question

After KDEL mutation, it became KEEL. Where did the mutation happen?

Hint:

Single amino acid changes, like in the KDEL to KEEL mutation, can significantly im- pact protein localization and function.

Answer 1

The mutation in the KDEL sequence occurred at the third position, where the amino acid Aspartic acid (D) was replaced by Glutamic acid (E). The KDEL sequence is a C-terminal signal that helps proteins return to the endoplasmic reticulum from the Golgi apparatus. The mutation from D to E affects the protein’s recognition and transport function.