Question:

Addisons disease results from :

Updated On: Aug 15, 2022
  • hypertrophy of gonads
  • hypo-secretion of adrenal cortex
  • hyperactivity of cells of Leydig
  • none of the above
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The Correct Option is B

Solution and Explanation

Addison's disease is an endocrine disorder, that manifests as primary adrenal insufficiency, which involves pathology in the adrenal glands. The condition develops as a result of bilateral adrenal cortex destruction. Damage to the adrenal cortex results in decreased production of adrenocortical hormones, with inadequate cortisol, aldosterone, and adrenal androgen produced. Autoimmune factors are responsible for the destruction of the adrenal glands in most cases, but infection (such as tuberculosis) hemorrhage, adrenal vein thrombosis, and carcinoma are also known to be the cause of a significant number of cases.
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Concepts Used:

Chemical Coordination and Integration

The chemical coordination and integration of all physiological functions in the animal body are jointly synchronized by the neural and endocrine systems. The control and coordination of body functions are executed by the endocrine glands. They are ductless glands that secrete severel hormones to control and coordinate body functions.

Human Endocrine System:

The human body has several endocrine glands located in different parts. They cover the pituitary gland, thymus, thyroid gland, pineal gland, parathyroid, pancreas (dual gland), adrenal gland, and gonads (testes and ovaries). The liver, kidney, heart, and gastrointestinal tract also produce hormones in small traces to harmonize the functioning of these organs.

The Hypothalamus comprises groups of secretory cells called nuclei which secrets various hormones. These hormones released by the hypothalamus are important in regulating the synthesis and secretion of pituitary hormones.

Functions of Endocrine Glands:

  • Pituitary Gland
  • Pineal Gland
  • Thyroid Gland
  • Parathyroid Gland
  • Thymus
  • Adrenal Gland
  • Pancreas
  • Testes
  • Ovary
  • Hormones of Kidney, Heart, and Gastrointestinal Tract