Question

A woman developed pain and crawling sensation on her legs at night. Clinical history of restless leg syndrome. Drug of choice ?

• A. Pramipexole
• B. Gabapentin
• C. Vitamin B₁₂
• D. Iron tablets

Answer 1

The Correct Option is A

Restless Leg Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, typically accompanied by uncomfortable sensations. This condition often presents at night or during periods of rest, thus affecting sleep quality.

The precise mechanism of RLS is not completely understood, but it is believed to be related to dopamine dysfunction in the brain. Hence, treatment often involves medications that target the dopaminergic system.

The drug of choice for treating Restless Leg Syndrome is Pramipexole. It is a dopamine agonist, which means it mimics the action of dopamine by binding to the dopamine receptors in the brain, thereby alleviating the symptoms associated with RLS.

Option	Action
Pramipexole	Dopamine agonist (Drug of choice for RLS)
Gabapentin	Anticonvulsant (Alternative treatment for RLS)
Vitamin B12	Vitamin supplementation (Not primary for RLS)
Iron tablets	Supplementation if iron deficiency is present

Therefore, based on the current understanding and clinical recommendations, Pramipexole is used as the primary treatment to manage Restless Leg Syndrome symptoms effectively.