Question:

A report published in Lancet Diabetes and Endocrinology has called for an overhaul of our understanding of obesity. An over-reliance on using Body Mass Index [BMI] as a metric has the peculiar effect of leading to both underdiagnosis and overdiagnosis of the condition. _____________________. BMI does not give accurate information about how fat is distributed in an individual's body. It frequently fails to capture the true state of health of an individual. A person's BMI may indicate they are "obese", but their organs and bodily functions may be absolutely normal. Every individual is a unique constellation - not only of genes and other biological variables, but also socio-economic conditions and habits.

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Look at the flow of logic from general to specific. The paragraph starts with a general problem (misdiagnosis), and the missing sentence should provide a general reason, which is then supported by the specific details that follow.
Updated On: Oct 14, 2025
  • BMI reading can help the doctor to accurately prescribe the appropriate dosage to reduce fat
  • This is because BMI does not provide a reliable picture of health, nor any direct measure of fat
  • Obesity is the end result of multiple factors and BMI can pinpoint the cause of the problem
  • Further, much of the information on diabetes, obesity or BMI available on social media is misleading
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The Correct Option is B

Solution and Explanation

Step 1: Understanding the Concept:
We need to find a sentence that fits logically between the statement that BMI leads to misdiagnosis and the explanation of BMI's specific failures.
Step 2: Detailed Explanation:


Preceding Sentence: "An over-reliance on using Body Mass Index [BMI] as a metric has the peculiar effect of leading to both underdiagnosis and overdiagnosis of the condition." This sentence states the problem: BMI is unreliable for diagnosis.
Following Sentence: "BMI does not give accurate information about how fat is distributed..." This sentence begins the specific explanation of *why* BMI is unreliable.
The Missing Link: The missing sentence should act as a bridge, stating the general reason for BMI's unreliability before the text dives into specifics.
Option (2) serves this purpose perfectly: "This is because BMI does not provide a reliable picture of health, nor any direct measure of fat." It provides a general reason ("not a reliable picture of health") that neatly summarizes the problem of misdiagnosis and logically introduces the subsequent, more detailed explanations about fat distribution and organ function. The other options contradict the paragraph's main argument or introduce irrelevant topics.
Step 3: Final Answer:
The most logical sentence is: "This is because BMI does not provide a reliable picture of health, nor any direct measure of fat".
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