Question

A patient is taking metronidazole for anaerobic infection. Which of the following should be avoided during this period.

• A. Alcohol
• B. Ciprofloxacin
• C. Rifampicin
• D. Colchicine

Answer 1

The Correct Option is A

In pharmacology, it's critical to understand drug interactions to ensure patient safety. Metronidazole is an antibiotic commonly used to treat anaerobic infections. While taking metronidazole, it's important to avoid certain substances due to potential adverse effects.

Interaction with Alcohol: 

One significant interaction with metronidazole is its effect when combined with alcohol. Metronidazole can inhibit the metabolism of alcohol, leading to an accumulation of acetaldehyde, a byproduct of ethanol metabolism. This results in a disulfiram-like reaction characterized by symptoms such as nausea, vomiting, flushing, headache, and palpitations. Therefore, patients are strongly advised to avoid alcohol consumption during and, preferably, for at least 48 hours after completing metronidazole therapy.

The other options provided include:

• Ciprofloxacin: An antibiotic that does not have a notable interaction with metronidazole.
• Rifampicin: Another antibiotic that may affect the metabolism of drugs but does not specifically have a contraindication with metronidazole.
• Colchicine: A medication used for gout, which does not have a known adverse interaction with metronidazole.

Based on this information, it is clear that alcohol should be avoided while taking metronidazole to prevent adverse reactions and enhance patient safety.