Question

A patient diagnosed with Rheumatoid arthritis was on medications. After 2 years, he developed a blurring vision and was found to have corneal opacity. Which drug is most likely to cause this?

• A. Sulfasalazine
• B. Chloroquine
• C. Methotrexate
• D. Leflunomide

Answer 1

The Correct Option is B

In patients with Rheumatoid arthritis, certain medications can lead to ocular side effects. When a patient develops blurring vision and corneal opacity, it's crucial to identify any drugs known to cause such side effects to adjust treatment accordingly. Among the medications listed:

• Sulfasalazine: Typically used for inflammatory bowel disease and rheumatoid arthritis, but does not commonly cause ocular toxicity.
• Chloroquine: Known for treating malaria and autoimmune diseases. It can cause ocular side effects such as corneal deposits (corneal opacity) and retinopathy, leading to blurred vision, particularly with long-term use.
• Methotrexate: An immunosuppressant used in various autoimmune conditions, with no significant direct ocular toxicity.
• Leflunomide: Another disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis, with little to no known ocular side effects.

Based on the symptoms of blurring vision and corneal opacity, Chloroquine is the most likely drug responsible due to its known ocular side effects.