Question

A drug with high plasma binding protein property has which of the following properties?

• A. Less GFR
• B. Less drug interaction
• C. Higher volume of distribution
• D. Less tubular secretion

Answer 1

The Correct Option is A

To determine which property a drug with high plasma protein binding has, understand these key points:

• Plasma Protein Binding: Drugs with high plasma protein binding attach extensively to plasma proteins, like albumin. Only unbound drugs can be filtered by the kidneys.
• Glomerular Filtration Rate (GFR): It measures how well the kidneys filter blood. Drugs bound to plasma proteins are not filtered, thus reducing GFR.
• Correct Property: High plasma protein binding drugs exhibit less GFR because they remain in circulation bound to proteins, reducing their availability for filtration in the kidneys.

Conclusion: The correct property for a drug with high plasma binding protein is Less GFR.