Question

A child presenting with whitish pupillary reflex was treated with enucleation. Histopathology of the specimen showed Flexner Wintersteiner rosettes. What is the diagnosis?

• A. Retinoblastoma
• B. Rhabdomyosarcoma
• C. Medulloblastoma
• D. Astrocytoma

Answer 1

The Correct Option is A

The correct diagnosis for a child presenting with a whitish pupillary reflex, treated with enucleation, and whose histopathology specimen showed Flexner Wintersteiner rosettes is Retinoblastoma.

The key clinical feature here is the "whitish pupillary reflex," also known as leukocoria, which is a common presentation in children with retinoblastoma. Enucleation, or surgical removal of the eye, is a treatment option for advanced cases of retinoblastoma. Moreover, the histopathological finding of Flexner Wintersteiner rosettes is characteristic of retinoblastoma. These rosettes are indicative of a well-differentiated tumor and are formed by tumor cells radially arranged around a central lumen, reflecting the photoreceptor differentiation of the tumor cells.

Clinical Feature	Significance
Whitish Pupillary Reflex (Leukocoria)	Common sign in retinoblastoma
Enucleation	Treatment for advanced cases
Flexner Wintersteiner Rosettes	Histopathological finding specific to retinoblastoma

Based on these features, the most accurate diagnosis is retinoblastoma.