Question

A child presented with dehydration and was supplemented with ORS solution for management. Which of the following receptors help in the absorption of glucose fromGIT?

• A. SGLT 1
• B. SGLT 2
• C. GLUT 1
• D. GLUT 2

Answer 1

The Correct Option is A

To understand which receptor is responsible for the absorption of glucose from the gastrointestinal tract (GIT), it's essential to delve into the structure and function of these receptors.

1. SGLT 1 (Sodium-Glucose Linked Transporter 1): This transporter is located in the intestinal epithelium and is primarily responsible for the absorption of glucose and galactose from the lumen of the intestine. It functions by coupling the transport of glucose with sodium ions, allowing glucose to be absorbed against its concentration gradient.

2. SGLT 2: This transporter is primarily found in the renal proximal tubules and plays a major role in the reabsorption of glucose from the filtrate back into the blood. It does not play a significant role in GIT glucose absorption.

3. GLUT 1: This is a glucose transporter located in various tissues, yet it is not specialized for glucose absorption in the gut.

4. GLUT 2: This is a bidirectional glucose transporter present in liver, pancreatic beta cells, and kidney. While it is involved in glucose transport, its role in the gut is mainly in the release of absorbed glucose into the bloodstream, not the initial absorption from the luminal side.

Given this information, the correct receptor responsible for glucose absorption from the gastrointestinal tract when supplemented with ORS is SGLT 1.