Question

Write chemical equation for five reactions of preparation of Amine.

Hint:

Hoffmann degradation is used to prepare primary amines without increasing the carbon chain length.

Answer 1

Step 1: Reduction of Nitro Compounds \[ R-NO_2 + 6[H] \xrightarrow{Sn/HCl} R-NH_2 + 2H_2O \] Step 2: Reduction of Amides \[ R-CONH_2 + 4[H] \xrightarrow{LiAlH_4} R-NH_2 + H_2O \] Step 3: Hoffmann Bromamide Degradation \[ R-CONH_2 + Br_2 + 4NaOH \rightarrow R-NH_2 + Na_2CO_3 + 2NaBr + 2H_2O \] Step 4: Gabriel Phthalimide Synthesis \[ C_6H_4(CO)_2N-K + R-X \rightarrow C_6H_4(CO)_2NR + KX \] \[ C_6H_4(CO)_2NR + H_2NNH_2 \rightarrow R-NH_2 + C_6H_4(CO)_2N_2H_2 \] Step 5: Alkylation of Ammonia \[ NH_3 + R-X \rightarrow R-NH_2 + HX \]