Chronic alcoholics are often deficient in thiamine (Vitamin B1), which is essential for carbohydrate metabolism. Alcohol interferes with thiamine absorption and its storage in the liver, leading to a deficiency. Thiamine deficiency can result in conditions such as Wernicke-Korsakoff syndrome, which is characterized by confusion, ataxia, and neuropathy. While other vitamins like riboflavin (B2) and vitamin A may also be deficient in alcoholics, thiamine deficiency is the most common and significant in this population.