Question

Which one of the following shows allosteric inhibition ?

• A. Malonic acid & succinate
• B. 2, 3 BPG
• C. Amino acid alanine & pyruvate kinase
• D. Citrate

Answer 1

The Correct Option is B

In biochemical pathways, allosteric inhibition refers to the regulation of a protein by binding to a specific site other than the protein's active site. This process alters the protein's activity.

1. Malonic acid & succinate: Malonic acid acts as a competitive inhibitor of succinate dehydrogenase, not allosteric.

2. 2, 3 BPG: This binds to hemoglobin and decreases oxygen affinity, functioning as an allosteric inhibitor.

3. Amino acid alanine & pyruvate kinase: Alanine inhibits pyruvate kinase allosterically to decrease glycolysis when the cell does not need energy.

4. Citrate: Acts as an allosteric inhibitor in glycolysis but is not specifically described here as allosteric inhibition.

The correct answer showcasing a distinct mechanism of allosteric inhibition is 2, 3 BPG, as it distinctly alters the function of hemoglobin through allosteric mechanisms to regulate oxygen delivery.