The word "amuse” means to entertain or delight.
Option A: "annoy" — This is the opposite, meaning to irritate or bother.
Option B: "interest" — This is close to amuse in a positive emotional sense.
Option C: "enliven" — Also similar, means to make more lively or fun.
Option D: "please" — Also a synonym, means to give pleasure.
Thus, the correct antonym of amuse is annoy.