Question

Which of the following terms is used to describe the “partial or complete separation of the top or body crowns of a tablet from the main body of the tablet”?

• A. Lamination
• B. Capping
• C. Picking
• D. Mottling

Answer 1

The Correct Option is B

In the field of pharmaceutics, understanding the various defects that can occur during the tablet manufacturing process is vital. One of these defects is "capping."

Explanation:

• Capping: This term refers to the partial or complete separation of the top or bottom crowns of a tablet from the main body. It often occurs when air is trapped in the compact during compression or due to incorrect formulation.
• Lamination: This defect involves the separation of the tablet into two or more distinct horizontal layers. It is different from capping as it involves the entire tablet, not just the crown.
• Picking: This is related to material from a tablet picking and adhering to the punches. It usually results in rough spots on the tablet surface or missing logos/text.
• Mottling: This refers to an uneven distribution of color on the tablet's surface, leading to a mottled appearance. It does not involve physical separation or structural failure.

Based on these definitions, the correct answer to the question, "Which of the following terms is used to describe the 'partial or complete separation of the top or body crowns of a tablet from the main body of the tablet'?" is Capping.

This identification helps in diagnosing manufacturing issues and ensuring the quality of the pharmaceutical tablets.