Question

Which of the following substances is used as an inactivating agent for sulfonamides?

• A. PABA (Para Amino Benzoic Acid)
• B. Penicillinase
• C. Acetyl Transferase
• D. Penicillamine

Hint:

Sulfonamides mimic PABA → PABA excess = sulfonamide inactivation.

Answer 1

The Correct Option is A

PABA competes with sulfonamides for incorporation into folic acid synthesis in bacteria. Because sulfonamides act as PABA analogs, an excess of PABA can inactivate or reduce the effectiveness of sulfonamides.