Question

Which of the following statements is untrue when comparing 3D QSAR with conventional QSAR?

• A. Only drugs of the same structural class should be studied by 3D QSAR or QSAR.
• B. 3D QSAR has a predictive quality unlike QSAR.
• C. Experimental parameters are not required by 3D QSAR, but are for QSAR.
• D. Results can be shown graphically in 3D QSAR, but not with QSAR.

Hint:

Which of the following statements is untrue when comparing 3D QSAR with conventional QSAR?

Answer 1

The Correct Option is A

Step 1: Understanding QSAR and 3D QSAR - QSAR (Quantitative Structure-Activity Relationship) is a computational technique that predicts biological activity based on the structural properties of molecules. - 3D QSAR extends QSAR by incorporating three-dimensional molecular features, such as steric, electrostatic, and hydrophobic interactions.

Step 2: Evaluating the Given Options - (A) Only drugs of the same structural class should be studied by 3D QSAR or QSAR. (Incorrect Statement) - This statement is incorrect because 3D QSAR can study drugs of different structural classes by analyzing their three-dimensional properties, rather than relying solely on chemical structure. - (B) 3D QSAR has a predictive quality unlike QSAR. (True Statement) - Both QSAR and 3D QSAR are predictive models, but 3D QSAR provides more refined predictive capabilities due to its incorporation of 3D molecular features. - (C) Experimental parameters are not required by 3D QSAR, but are for QSAR. (True Statement) - Traditional QSAR models rely heavily on experimental values such as pKa, logP, and molecular weight, while 3D QSAR utilizes computational molecular modeling. - (D) Results can be shown graphically in 3D QSAR, but not with QSAR. (True Statement) - 3D QSAR allows visualization of molecular features using contour maps and surface plots, which is not typically possible in traditional QSAR.

Step 3: Selecting the Correct Answer - Since option (A) is incorrect, it is the correct answer to the question.