In X-linked recessive inheritance, an affected mother has two defective X chromosomes and will pass one defective X chromosome to all her sons. Since males inherit only one X chromosome, they will always express the trait if they inherit the defective gene. Females are less frequently affected because they require two copies of the defective gene to show the trait.
List I | List II |
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(A) Radiation hybrid mapping | (I) DNA can be cut into large fragments and circularized for use in chromosome walking |
(B) Sequence tagged site (STS) mapping | (II) Useful for cloning of overlapping DNA fragments (restricted to about 200 kb) |
(C) Chromosome jumping | (III) Fragment genome into large pieces and locate markers and genes |
(D) Chromosome walking | (IV) Applicable to any part of DNA sequence if some sequence information is available |