Question

Which of the following statement is correct about acute fatty liver of pregnancy?

• A. Occurs in 1 in 1000 pregnancy
• B. Mostly seen in last trimester
• C. Common if female fetus is present
• D. May be associated with decreased uric acid

Answer 1

The Correct Option is B

Acute fatty liver of pregnancy (AFLP) is a rare, potentially life-threatening condition that affects pregnant women. It is characterized by a sudden, acute accumulation of fat in the liver cells, which can lead to liver failure and severe maternal and fetal complications if not managed timely. Understanding this condition involves recognizing the typical presentation and risk factors.

• The incidence of AFLP is estimated to occur in approximately 1 in 7,000 to 1 in 13,000 pregnancies, making the option "Occurs in 1 in 1000 pregnancy" inaccurate.
• It predominantly manifests in the third trimester, often after 30 weeks of gestation, which aligns with the statement "Mostly seen in last trimester" as the correct option.
• The condition is not influenced by the sex of the fetus, thus the statement "Common if female fetus is present" is incorrect.
• AFLP is usually associated with elevated uric acid levels due to impaired renal function, contradicting the statement "May be associated with decreased uric acid."

Therefore, the most accurate statement regarding acute fatty liver of pregnancy is: "Mostly seen in last trimester."