The correct plural of "mouse" is "mice", not "mices".
Additionally, for plural subjects like "mice", the correct verb form is "live" or "have lived", not "has been living".
The correct sentence is:
"Mice have lived in holes."
Thus, the correct answer is Option D ("Mice have lived in holes").
Among scientists, the discovery of the double helix structure of DNA and the genetic code it incorporates is widely regarded to be one of the most significant scientific discovery of the twentieth century.