Question

Which of the following is true for bone tissue cell differentiation and maturation?

• A. Osteogenic→Osteblasts→Osteocytes
• B. Osteogenic→Osteblasts→Osteoclasts
• C. Osteocytes →Osteogenic→Osteblasts
• D. Ostoclasts→Osteblasts→Osteocytes

Answer 1

The Correct Option is C

The question provided revolves around the process of cell differentiation and maturation within bone tissue. The context is important as it pertains to the development of bone cells and their functional roles.

To address this question, let's analyze each given option and identify the correct sequence of differentiation and maturation of bone cells:

1. Osteogenic → Osteoblasts → Osteocytes: This is the correct order of differentiation for bone cell development. Here's why:
   • Osteogenic\ cells: These are the precursor or stem cells in the bone that have the potential to develop into osteoblasts. They are undifferentiated and play a crucial role in the bone regeneration process.
   • Osteoblasts: These cells arise from osteogenic cells and are responsible for the synthesis of bone matrix and mineralization. They are actively involved in forming new bone tissue.
   • Osteocytes: Once osteoblasts become embedded in the bone matrix they secrete, they mature into osteocytes. Osteocytes are mature bone cells that maintain the bone matrix.
2. Osteogenic → Osteoblasts → Osteoclasts: This option is incorrect because osteoclasts do not derive from osteogenic cells. Osteoclasts are derived from the monocyte/macrophage lineage and are responsible for bone resorption.
3. Osteocytes → Osteogenic → Osteoblasts: This sequence is incorrect as osteocytes cannot revert back to osteogenic cells, making this an illogical sequence in the differentiation process.
4. Osteoclasts → Osteoblasts → Osteocytes: This is incorrect. Osteoclasts are involved in bone resorption and come from a different lineage than osteoblasts and osteocytes.

Conclusively, the logical and factual sequence of bone cell differentiation and maturation is: Osteogenic → Osteoblasts → Osteocytes.