Question

Which of the following is the TCA cycle metabolite used in the detoxification of ammonia in the brain?

• A. Ornithine
• B. Alpha-ketoglutarate
• C. Oxaloacetate
• D. Glycine

Hint:

ketoglutarate plays an important role in the detoxification of ammonia in the brain by being part of the glutamate-glutamine cycle.

Answer 1

The Correct Option is B

- ketoglutarate is involved in the metabolism of ammonia in the brain. It is a key metabolite in the TCA cycle and is involved in the glutamate-glutamine cycle, which helps detoxify ammonia.
- Ornithine is involved in the urea cycle but not directly in ammonia detoxification in the brain.

Conclusion: ketoglutarate is the metabolite involved in detoxifying ammonia in the brain, making option (b) the correct answer.